Growth Hormone, Cardiomyocyte Contractile Reserve, and Heart Failure
نویسندگان
چکیده
منابع مشابه
Growth hormone, cardiomyocyte contractile reserve, and heart failure.
In this issue of Circulation, Tajima et al 1 report that recombinant human growth hormone (GH) (3.5 mg z kg z d) given for 2 weeks, while not affecting baseline function, restored myocardial contractile reserve in cardiomyocytes isolated from rats 4 to 6 weeks after myocardial infarction (MI) compared with vehicle-treated post-MI rats. In addition, the peak of the Ca transient, which was normal...
متن کاملTreatment with growth hormone enhances contractile reserve and intracellular calcium transients in myocytes from rats with postinfarction heart failure.
BACKGROUND Recombinant human growth hormone (GH) improves in vivo cardiac function in rats with postinfarction heart failure (MI). We examined the effects of growth hormone (14 days of 3.5 mg. kg-1. d-1 begun 4 weeks after MI) on contractile reserve in left ventricular myocytes from rats with chronic postinfarction heart failure. METHODS AND RESULTS Cell shortening and [Ca2+]i were measured w...
متن کاملCardiomyocyte and Heart Failure
In recent years, outcome of therapy in patients with heart failure is going up. Many clinical trials have demonstrated that renin angiotensin aldosterone system inhibitors and βblockers have functional roles in stabilizing and /or reversing cardiac remodeling via suppression of the excessive activation of renin angiotensin aldosterone and the adrenergic nervous system. Additively, the cardiac r...
متن کاملGrowth hormone in chronic heart failure.
3. Lualdi JC, Goldhaber SZ. Right ventricular dysfunction after acute pulmonary embolism: pathophysiologic factors, detection, and therapeutic implications. Am Heart J. 1995;130:1276-1282. 4. Kasper W, Konstantinides S, Geibel A, Tiede N, Krause T, Just H. Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary e...
متن کاملAlterations in left ventricular mechanics, energetics, and contractile reserve in experimental heart failure.
The contributions of changes in primary systolic and diastolic properties, limitations of contractile reserve, and alterations in energy efficiency to the left ventricular dysfunction seen with chronic pacing tachycardia were investigated. Seven dogs (heart failure group) were ventricularly paced at 250 beats per minute for 26.3 +/- 2.9 days and compared with a separate control group (n = 8). S...
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ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.99.1.15